ITPR Distinguished Seminar –Systems Biology and Omics-driven Approaches for Target Identification and Drug Discovery: from the Perspective of Cell-cell Communication
Speaker Stephen T. Wong, PhD, PE. Houston Methodist Hospital and Weill Cornell Medicine Date : 5 December 2022 Time : 10:00am – 12:00nn Venue : WLB103
Abstract During the past decade, bioinformatics-driven approaches have been emerged to be a powerful means for delineating mechanisms of dynamic, complex cell-cell interactions within tissue microenvironment and for discovering novel targets for drug repositioning and development. This short talk will present an overview of a multicellular systems biology strategy to understand the underlying cell-cell communication within tumor microenvironment using cell-specific, single cell, and spatial transcriptomics, multiplex imaging, and multi-cellular crosstalk modeling in a comprehensive, unbiased manner. We will provide examples of applications targeting tumor microenvironment of different organs, such as the bones, brain, lungs, and ovaries to illustrate the power of systems biology modeling for hypotheses generation, tumor heterogeneity delineation, and target and drug discovery, as well as ongoing extensions to other diseases such as Alzheimer’s and Idiopathic pulmonary fibrosis.
To attend the lecture above, please fill in the registration form below by 2 December 2022 (Fri) noon. For enquiries, please email to itpr@hkbu.edu.hk.